充血性心力衰竭患者血浆一氧化氮、内皮素含量变化及其意义

CHANGES OF PLASMA NITRIC OXIDE AND ENDOTHELIN LEVELS IN PATIENTS WITH CONGESTIVE HEART FAILURE

目的 探讨充血性心力衰竭(CHF)患者血浆一氧化氮(NO)和内皮素(ET)含量变化及其关系。方法 检测65例CHF患者血浆NO和ET含量,另选30例健康体检者作为正常对照组。结果 CHF患者血浆NO和ET水平明显高于正常对照组(P<0.01)。且心衰程度越重,NO和ET水平越高。直线相关分析表明:NO与ET呈正相关(r=0.6457,P<0.001)。结论 血浆NO和ET水平增高是CHF病理生理特征之一。NO和ET共同参与CHF的发生发展过程。

Objective To study the clinical significance of changes in plasma nitric oxide(NO) and en-dothelin(ET) levels in patients with congestive heart failure (CHF). Methods Levels of NO and ET in plasma were detected in 65 patients with CHF. 30 healthy subjects served as normal control. Results Levels of NO and ET in patients were significantly higher than those in normal subjects (all P< 0.01). The increase of NO and ET levels were significant in CHF patients. There was significant correlation between NO and ET levels (r = 0. 6427, P < 0. 001). Conclusion The increase in levels of plasma NO and ET might be one of the pathologic physiology characteristics in CHF. NO and ET are both involved in the development of CHF.