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吡格列酮对链脲佐菌素诱导的糖尿病大鼠肾脏保护作用研究 被引量：2

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作者 孙海艳 屈会起 邱明才
机构地区 天津医科大学总医院内分泌科
出处 《中华内科杂志》 CAS CSCD 北大核心 2003年第8期579-580,共2页 Chinese Journal of Internal Medicine
基金 天津市教委科研基金资助项目 (9910 0 6)
关键词 吡格列酮 链脲佐菌素 糖尿病 大鼠 肾功能 病理形态学 肾间质纤维化
分类号 R587.1 [医药卫生—内分泌]
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  • 2Guan Y, Breyer MD.Peroxisome proliferator-activated receptors(PPARs): novel therapeutic targets in renal disease. Kidney Int, 2001, 60(1): 14～30.
  • 3JUGE-Aubry CE, Hamma E, Siegrist-kaiser C, et al. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor a by phosphorylation of a ligand-independent trans-activating domain. J Biol Chem, 1999,274(15): 10 505～10.
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同被引文献12

  • 1李贤厚,段滨红,王亦薇,冯琨,杨玉芝.罗格列酮治疗2型糖尿病合并肾病尿微量白蛋白的疗效观察[J].中国误诊学杂志,2004,4(9):1432-1432. 被引量：5
  • 2叶任高,陆再英,主编.内科学[M].第6版.北京:人民卫生出版社,2005,28-30.
  • 3Suzuki D, Toyoda M, Yamamoto N, et al. Relationship between the expression of advanced glyeation end-products (AGE) and the receptor for AGE (RAGE) mRNA in diabetic nephropathy. Intern Med, 2006, 45:435-441.
  • 4Okada T, Wada J, Hida K, et al.Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. Diabetes, 2006,55: 1666 -1677.
  • 5Marx N, Walcher D, Ivanova N, et al. Thiazolidinediones reduce endothelial expression of receptors for advanced glycation end products. Diabetes, 2004,53:2662-2668.
  • 6Tang SC, Leung JC, Chan LY, et al. Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferatoractivated receptor-gamma agonist. J Am Sec Nephrol, 2006,17:1633- 1643.
  • 7Wendt TM, Tanji N, Guo J, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol, 2003,162 : 1123-1137.
  • 8Jensen LJ, Denner L, Schrijvers BF, et al. Renal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice. J Endocfinol, 2006,188:493-501.
  • 9Bavirti S, Ghanaat F, Taydk JA. Peroxisome proliferator-activated receptor-gamma agonist increases both low-density lipoprotein cholesterol particle size and small high-density lipoprotein cholesterol in patientS with type 2 diabetes independent of diabetic control. Endocrine Practice, 2003,9:487-489.
  • 10Ma LJ, Marcantoni C, Linton MF, et al. Peroxisome proliferator-activated receptor-γ, agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int, 2001,59 : 1899-1910.

引证文献2

中华内科杂志
2003年 第8期

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