腹腔镜垂直束带式胃减容术治疗单纯性重度肥胖患者的疗效及安全性评价

EVALUATION ON EFFECTS AND SAFETY OF LAPAROSCOPIC VERTICAL BANDING GASTROPLASTY IN MORBID OBESE SUBJECTS

为评价腹腔镜垂直束带式胃减容术(LVBG)治疗中国人单纯性重度肥胖患者的疗效及安全性 ,比较 2 6例中国重度肥胖患者LVBG术前与术后 1年糖、脂代谢及肥胖相关临床指标变化。结果发现 ,LVBG术后 1年 ,患者平均减重 2 2 98± 14 2 7kg,体重指数(BMI)减少 9 3 1± 5 13kg/m2 ,多余体重减少百分比 (EWL % ) 4 7 19%± 3 1 17% ;随着体重、BMI的明显下降 ,患者的腰围、腰臀比、收缩压、空腹胰岛素 (FIRI)、胰岛素抵抗指数 (HOMA IR)、甘油三酯、总胆固醇/高密度脂蛋白、谷丙转氨酶及肌酐均显著降低 ,高密度脂蛋白显著增高。手术前后BMI及EWL %变化均与FIRI及HOMA IR变化呈显著正相关。研究表明 ,对于单纯性重度肥胖患者而言 。

To evaluate the effects and safety of laparoscopic vertical banding gastroplasty (LVBG) in morbid obese subjects. The clinical data related to the metabolism of glucose, lipids and obesity in 26 obese Chinese patients with LVBG one year before and after the surgery were analyzed. The results showed that 1 year after LVBG, there was a reduction of 22.98±14.27kg in body weight, 9.31±5.13kg/m 2 in BMI, and a reduction of 47.19%±31.17% of body over-weight (EWL%) in these patients. BMI, waist, waist hip ratio, systolic blood pressure, fasting insulin, insulin resistance based on HOMA, triglyceride, cholesterol/HDL, ALT and blood creatine were decreased with reduction of body weight and BMI after LVBG. Changes in BMI and EWL% were significantly correlated with those of fasting insulin and insulin resistance. It is suggested that LVBG is effective and safe for reducing body weight and improving metabolism in the markedly obese patients.