微血管密度测定在子宫内膜癌病变发展中的价值

The Value of the Measurement of Microvessel Density in the Development of Endometrial Carcinoma

目的 探讨血管生成活性在子宫内膜癌发展中的价值。方法 采用Ⅷ因子相关抗原为标志物 ,以免疫组化技术对正常子宫内膜、不典型增生内膜 ,子宫内膜癌组织进行微血管密度 (MVD)测定。结果 ①正常组与内膜癌组比较 (P <0 .0 1) ,正常组与不典型增生组比较 (P <0 .0 5 ) ;从正常内膜、不典型增生到内膜癌组织内MVD逐渐增多 (P <0 .0 5 )。②内膜癌组织内MVD与肿瘤细胞分化程度有关 (P <0 .0 5 )。结论 临床采用MVD测定对子宫内膜增生病变发展和追随检查具有重要价值 ,同时MVD测定可作为判断子宫内膜癌预后的指标之一。

Objective To study the value of the activity of angiogenesis in the development of endometrial carcinoma.Methods To assaged the microvessel density(MVD) of normal endometrium,endometrial atypical hyperplasia and endometrial carcinoma by immunohisto chemical method,using the Faetor Ⅷ related antigen as the marker.Results ①There was a significant difference in MVD between the normal group and the cancer group (P<0.01).And also there was a significant difference in MVD between the normal group and the atypical hyperplasia group (P<0.05).The MVD was gradually increased from normal endometrium and atypical hyperplasia to endometrial carcinoma (P<0.05).②Intratumor microvessel density is associated with the differentiation of tumor (P<0.05). Conclusion The measurement of MVD is of great value in monitoring the development of endometrial hyperplasia.Meanwhile the measurement of MVD can be one of indications to predict the prognosis of endometrial carcinoma.