膀胱灌注、粘膜下定期注射丝裂霉素C预防膀胱癌术后复发疗效观察

PREVENTION OF BLADDER CARCINOMA RECURRENCE:MITOMYCIN C INJECTION AND PERFUSION

目的 :比较单纯膀胱灌注丝裂霉素C(MMC)和膀胱灌注法、定期粘膜下注射MMC预防膀胱肿瘤术后复发的疗效 ;方法 :3 7例膀胱肿瘤术后患者分为两组 ,分别接受单纯膀胱灌注MMC和膀胱灌注及定期粘膜下注射MMC治疗 ;结果 :随访 (2 4～ 3 4)个月 ,单纯膀胱灌注组 1 5例 ,复发 6例 ,占 40 % ;膀胱灌注、定期粘膜下注射组 2 2例 ,复发 4例 ,占1 8.1 8% ,两组对比差别有显著性 (P <0 .0 5) ;结论 :膀胱灌注、定期粘膜下注射MMC预防膀胱肿瘤术后复发效果满意 。

Objective:To compare the effects of mitomycin C on prevention of bladder carcimoma recurrence in various treated ways.Method:A total of 37 postoperative patient with bladder carcinoma were divided into two groups in which the mitomycin C was given by intravesical perfusion or intravesical perfusion+submucosa injection (combined group) separately.The efficiency was recorded and followed up for 12 to 34 months in the two groups.Result:The recurrent rate of bladder carcinoma in intravesical perfusion group and combined group was 40.00% and 18.18% separately.There was a significant difference (P<0.05).Conclusion:The recurrent rate of bladder carcinoma could be better prevented by inravesical perfusion combined with submucosa injection therapy with mitomycin C after operation.