肺炎衣原体感染与冠心病的相关性初探

Correlation of chlamydia pneumonia infection and coronary heart disease

目的 探讨肺炎衣原体 (CP)感染与冠心病 (CHD)的相互关系。方法 应用酶联免疫方法检测 170例CHD组及 5 0例健康对照组血清CP特异性抗体IgG ,同时应用全自动生化分析仪测定血清总胆固醇(TC)、甘油三酯 (TG)、载脂蛋白A、载脂蛋白B、高密度脂蛋白浓度。结果 CHD组CP阳性率 74 .11% ,对照组 2 4 % ,两组相比有显著差异 (P <0 .0 1)。CP阳性的CHD患者血清TC、TG浓度高于CP阴性患者 ,HDL浓度低于CP阴性患者。结论 CP感染和CHD发生有密切关系。CP可能通过影响动脉粥样硬化斑块的稳定性及干扰血脂代谢而影响CHD的发生与发展.

Objective To explore the relation of chlamydia pneumonia(CP) and coronary heart disease(CHD). Methods CP-specific IgG antibodies were measured by using enzyme linked immunosorbent assay(ELISA) and total cholesterol(TC),triglyceride(TG),apolipoprotein A(apoA),apolloprotein B(apoB),high density lipoprotein(HDL)were measured by total automatic biochemistry analyzer in 130 cases of CHD and in 50 healthy controls. Results The rates of seropositive for CP were 74.11% in CHD patients and 24% in control group,with significant difference(P<0.01). TC and TG in the patients positive for CP were higher than that in the patients negative for CP,while HDL was lower than that in the patients negative for CP. Conclusion CP infection is closely related with CHD because CP may affect CHD occurrence and development by influencing stability of atherosclerosis plague and interfering with lipid metabolism.