缓解期慢性阻塞性肺疾病患者呼吸氦氧混合气后肺活量及其组成的变化

The change of vital capacity and its components after breathing Helium-Oxygen mixture in stable patients with chronic obstructive pulmonary disease

目的 探讨缓解期慢性阻塞性肺疾病 (COPD)患者呼吸氦氧混合气 (He O2 )后肺活量 (VC)及其组成的变化。方法 测定 37例缓解期COPD患者的VC及其组成补呼气容积 (ERV)和深吸气量 (IC) ,并对所得数据进行统计学处理。结果 呼吸He O2 后VC和ERV分别较呼吸空气时平均增加 2 2 .7%和 15 0 .1% ,二者比较差异显著 (P <0 .0 5 ) ,IC平均下降 3.89% ,但无显著性差异 (P >0 .0 5 )。结论 缓解期COPD患者呼吸He O2 后肺活量及其组成具有健康人呼吸He O2 后类似的反应 ,表明He O2 具有对肺组织进一步回缩的作用 ,这可能是He O2 具有治疗阻塞性呼吸道疾病的一种非物理性原因 ,其机理有待研究阐明。

Objective To investigate the change of vital capacity and its components after breathing helium-oxygen mixture(He-O 2) in stable patients with chronic obstructive pulmonary disease(COPD). Methods Vital capacity(VC) and its component expiratory capacity(ERV) and inspiratory capacity(IC) were detected in 37 stable patients with COPD and the data were analyzed statistically. Results After breathing He-O 2,VC and ERV increased by 33.7% and 150.1% respectively,compared with breathing air(P<0.05),while IC decreased by 87.3% but there was no significant difference(P>0.05). Conclusion The change of vital capacity and its components after breathing He-O 2 in stable patients with COPD is similar to healthy people,which indicates that He-O 2 might induce further retraction of pulmonary tissue and this may be one non-physical reason that He-O 2 can treat COPD effectively,but the mechanism is to be elucidated.