摘要
Objective To assess the relationship between HOMA-estimated insulin resistance and risk fac-tors of cardiovascular disease in the general population. Methods 268 eligible subjects of Pudong ShangGan community, aged 45-80 years, volunteered to participate in this cross-sectional survey. Fasting insulin was measured by means of a radioimmunoassay. Results Anthropometric parameters ,fasting blood glucose and insulin, increased in a linear fashion across quartiles of HOMA-IR after adjustment for age and sex. HOMA-IR was significantly associated with measures of anthropometry (BMI,r = 0. 30; waist circumference, r =0. 35; and waist-to-hip ratio,r =0.21), fasting (glucose,r =0. 41; insulin,r=0. 71), and cardiovascular risk factors ( cholesterol, r = 0. 23; triglyceride,r = 0. 31; systolic blood pressure,r= 0. 25; and diastolic blood pressure, r = 0. 20; all P < 0. 0001). In logistic regression analysis, odds ratios indicate that individuals with obesity ( high levels of BMI and waist circumference) were more than 4 times likely to have elevated HOMA-IR. With increase of log triglycerides, the risk of having elevated HOMA-IR increased more than 2. 4 times. For increase in systolic and diastolic blood pressure, the likelihood of having elevated HOMA-IR increased >1. 8 times. Conclusion HOMA-IR was significantly and independently associated with risk factors of cardiovascular disease in this study.
Objective To assess the relationship between HOMA-estimated insulin resistance and risk factors of cardiovascular disease in the general population. Methods 268 eligible subjects of Pudong ShangGan communtty, aged 43～80 years, volunteered to participate in this cross-sectional survey. Fasting insulin was measured by means of a radioimmunoassay. Results Anthropometric parameters ,fasting blood glucose and insulin, increased in a linear fashion across quartiles of HOMA-1R after adjustment for age and sex. HOMA-1R was significantly associated with measures of anthropometry ( BMI,r=0.30;waist circumference, r =0.35; and waist-to-hip ratio, r=0.21 ), fasting ( glucose, r=0.41 ; insulin, r=0.71 ), and cardiovascular risk factors ( cholesterol, r=0.23; triglyceride, r=0.31;systolic blood pressure, r=0.25;and diastolic blood pressure, r=0.20;all P<0.0001 ). In logistic regression analysis, odds ratios indicate that individuals with obesity ( high levels of BM1 and waist circumference) were more than 4 times likely to have elevated HOMA-1R. With increase of log triglycerides,the risk of having elevated HOMA-1R increased more than 2. 4 times. For increase in systolic and diastolic blood pressure, the likelihood of having elevated HOMA-1R increased>1.8 times. Conclusion HOMA-1R was significantly and independently associated with risk factors of cardiovascular disease in this study.
基金
Supported by the foundation from Shanghai Science and Technology Commission (00HX020)
by the foundation from Shanghai Public Administration (99427)
