血管内皮生长因子促血管形成作用及其调控

Effect of vascular endothelial growth factor on angiogenesis and its regulation

血管内皮生长因子是一种具有促血管生成活性的功能性蛋白 ,它通过与特异性受体的结合 ,发挥生理功能 :(1 )促血管内皮细胞分裂从而促进新生血管形成 ;(2 )增强血管通透性的功能。其活性的发挥受到多因素、多水平的调节 ,如 :缺氧、癌基因、细胞因子、细胞间质成分等。

Vascular endothelial growth factor(VEGF) is a kind of protein facilitating the angiogenesis,which can combine with its special receptor. The 2 major functions of VEGF are:(1) accelerate the proliferation of endothelial cells,leading to the formation of new vessels;(2) up regulation of the vessels permeability.The activity of the VEGF is regulated by various factors at different levels,such as: hypoxia, oncogene,the cytokine, the intercellular matrix, etc .The biological character and role of VEGF were summarized in this article with special emphasis on VEGF function and regulation.