PLLA/TCP复合骨组织载体框架的低温挤出成形

Low-temperature extrusion manufacturing of poly (L-lactic acid)/tricalcium phosphate composite scaffolds for bone tissue engineering

为制备骨组织工程的细胞与因子的三维载体框架,提出了聚左旋乳酸/磷酸三钙(PLLA/TCP)复合材料快速成形的低温挤出成形工艺,研究了此工艺制备骨组织载体框架的设备与工艺过程。分析了制备的载体框架的孔隙结构、孔隙率、力学性能,并通过犬桡骨20mm节段性缺损的修复实验分析了制备的载体框架的生物相容性、体内降解性能和骨传导性能。制备的载体框架具有良好的综合性能,可以作为骨组织再生修复的载体框架。

Lowtemperature extrusion manufacturing was used to form poly(Llactic acid)/tricalcium phosphate composite scaffolds for bone tissue engineering. The digitized manufacturing technique was based on layerbylayer manufacturing using rapid prototyping. This paper analyzes the manufacturing equipment and processing. The porous morphology, porosity and mechanical properties of the formed scaffolds were also analyzed. An in vivo experiment to repair a 20mm defect in a canine radius with the scaffolds shows that the scaffolds have good biocompatibility, biodegradation and bone conductance. The scaffolds have a good combination of properties and can be used for repairing bone tissue.