Synthesis of C-Nucleoside Analogues: 2-[2-(Hydroxymethyl)-1,3-dioxolan-5-yl]1,3-thiazole-4-carboxamide and 2-[2-(Mercaptometh-yl)-1,3-dioxolan-5-yl] 1,3-thiazole-4-carboxamide

Synthesis of C-Nucleoside Analogues: 2-[2-(Hydroxymethyl)-1,3-dioxolan-5-yl]1,3-thiazole-4-carboxamide and 2-[2-(Mercaptometh-yl)-1,3-dioxolan-5-yl] 1,3-thiazole-4-carboxamide

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摘要 Novel C-nucleosides of tiazofurin analogue (2-[2-(hydroxymethyl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide) and its thiol-substituted derivative (2-[2-(mercaptomethyl)-1,3-dioxolan -5-yl]1, 3-thiazole-4-carboxamide) were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1HNMR, 13CNMR and elemental analysis. Novel C-nucleosides of tiazofurin analogue (2-[2-(hydroxymethyl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide) and its thiol-substituted derivative (2-[2-(mercaptomethyl)-1,3-dioxolan -5-yl]1, 3-thiazole-4-carboxamide) were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1HNMR, 13CNMR and elemental analysis.

作者 DongMeiCAI MinJieLI DaLiangLI TianPaYOU

机构地区 DepartmentofChemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第2期163-166,共4页 中国化学快报（英文版）

关键词 C-NUCLEOSIDES tiazofurin selenazofurin 1 3-dioxolane thiol-substituted. C-Nucleosides, tiazofurin, selenazofurin, 1, 3-dioxolane, thiol-substituted.

分类号 O629.74 [理学—有机化学]

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Chinese Chemical Letters

2004年第2期

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Synthesis of C-Nucleoside Analogues: 2-[2-(Hydroxymethyl)-1,3-dioxolan-5-yl]1,3-thiazole-4-carboxamide and 2-[2-(Mercaptometh-yl)-1,3-dioxolan-5-yl] 1,3-thiazole-4-carboxamide

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