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Synthesis of New Fluorinated Podophyllotoxin Derivatives 被引量:2

Synthesis of New Fluorinated Podophyllotoxin Derivatives
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摘要 Five fluorinated podophyllotoxin derivatives were synthesized using dimethylamino- sulfurtrifluoride (DAST).
机构地区 DepartmentofChemistry
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第2期131-134,共4页 中国化学快报(英文版)
关键词 Podophyllotoxin derivatives FLUORINATION dimethylaminosulfur trifluoride (DAST). Podophyllotoxin derivatives, fluorination, dimethylaminosulfur trifluoride (DAST).
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  • 10[10]Compound 5: mp.211-213℃. 1H NMR (500MHz, CDCl3) δ ppm 6.83 (s, 1H), 6.54 (s, 1H), 6.53 (s, 1H), 6.01 (d, 2H, J=3.2 Hz), 5.20 (s, 1H), 4.83 (d, 1H, J=3.0 Hz), 4.51 (d, 2H, J=5.0 Hz), 4.28 (d, 1H, J=5.7 Hz), 3.85 (s, 3H), 3.48 (dd, 2H, J=5.7, 14.1 Hz), 2.81 (m, 1H).

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