微机控制的大鼠四路穿梭箱主动回避反应实验系统

Computer-controlled four-way shuttlebox experiment system for active avoid ance response of rats

目的:研制微机控制的四路穿梭箱主动回避反应实验系统,应用于认知神经科学、神经生理学、神经药理学等实验研究。方法:该系统由传感器、穿梭箱、刺激器、I/O接口、计算机及系统软件构成。以Windows操作系统作为研发平台,利用功能强大的可视化开发软件VisualC++.NET作为本系统开发工具。在硬件设计中,引进电磁兼容技术,使系统性能更加稳定。结果:本系统可同时精确地自动控制4只大鼠完成穿梭箱主动回避反应行为训练实验的全过程,从行为训练的自动控制到实验数据的实时采集、显示、实验结果打印及保存,实现了多路大鼠穿梭箱主动回避反应行为训练的自动化,无需实验者直接操作,节省了科研经费和人力,提高了工作效率。结论:该系统性能稳定、可靠,人机界面友好,操作简便;利用传感器检测动物行为活动,判断准确,定时精确。

AIM: To develop a computer-controlled four-way shuttlebox for active avo idance response in the research on cognitive neuroscience, neurophysiology and n europharmacology. METHOD: This system is composed of transducer, shuttle box, stimulator, I/O interface, computer and application software. Windows operating system was used as developing platform, and Visual C+ + was applied for system development.El ectromagnet compatible technique was introduced into the hardware design to ensu re the stability of the system. RESULTS:This system can control the whole procedure of active avoidance respo nse of 4 rats in shuttle box simultaneously.It can automatically accomplish the behavior training,real-time data acquisition and its displaying,and printing a nd saving of the experimental findings, which enhances the efficiency of the beh avioral experiment,and save the outlay and manpower. s CONCLUSION: This system is stable,reliable and easy to operate and has friend ly human interface. The transducers is accurate for detecting animal behavior i n terms of judgment and timing.