缺血性脑卒中预后与C反应蛋白水平变化的关系(英文)

Changes of C-reactive protein level and prognosis of ischemic stroke

目的:研究C反应蛋白(C-reactiveprotein,CRP)水平与脑梗死大小,颈动脉斑块及脑卒中预后的临床关系。方法:对纳入研究的所有缺血性脑卒中患者在发病后72h内抽取血清测定CRP水平,按脑卒中患者临床神经功能缺损程度评分标准(clinalneurologicfunctionaldefaultscoring,CNFDS)进行评分,所有患者进行CT/MRI及颈动脉超声检查。结果:在CRP异常组中,患者入院时的血糖水平及白细胞数明显高于正常组,脑梗死发生率明显高于腔隙性脑梗死(42例61.76%:23例43.40%,颈动脉斑块的发生率也较正常组高(32例65.30%:17例34.69%)。异常的CRP组中有较高的CNFDS评分CNFDS:中位数18(6～35):11(6～28),P=0.0001,曼-惠特尼U检验及严重的预后。结论:CRP水平是反映颈动脉斑块及脑卒中预后的一个重要标志物。

AIM:To assess the association of C-reactive protein(CRP) levels with infarc tion size,severity of carotid plaque and post-stroke prognosis of the patients . METHODS:In 121 stroke patients,serum CRP level was measured within 72 hours a fter the onset of ischemic stroke.All patients were scored by Clinical Neurologi c Functional Defect Scoring(CNFDS) and examined by CT/MRI and carotid duplex ult rasound. RESULTS:Patients with abnormal CRP had higher levels of blood sugar and great er number of leucocytes at admission as compared with those with normal CRP.The incidence of cerebral infarction was 61.76% (n=42),significantly higher than th at of lacunar infarction (43.40% ,n=23).The incidence of carotid plaque was 65. 30% ,also significantly higher than that among patients with normal CRP (34.69 % ,n=17).Higher CNFD scores and poorer clinical outcome were found in the patie nts with abnormally high CRP levels (P=0.000 1,P=0.000 1). CONCLUSION:CRP level can be an important indicator to reflect the severity of carotid plaque and to predict the clinical outcome of stroke patients.