含VE微胶囊的制备及其控制释放性能研究

Preparation of VE Microcapsules and Its Controlled Release Characteris tics

以天然维生素E(VE)为芯材,利用Shirasuporousglass(SPG)膜乳化结合液中干燥法,制备了粒径单分散的聚苯乙烯(PS)微胶囊.微胶囊的粒径为膜孔径的4倍,粒径单分散系数CV小于0.2.考察了改变PS和VE的比例及微胶囊的粒径对控制释放性能的影响.

Monodisperse polystyrene(PS)microcapsules containing vitamin E (VE)were prepared by mem-brane emulsification-dying in liquid technique.The diameter of microcapsules was about 4times the size of t he pore diameter of Shirasu porous glass(SPG)membrane,and the coefficient of variation(CV)of the microcapsule size was less than 0.2,showing a good monodispersity.Furthermore,the e ffects of the ratio of PS to VE(m/m)and the diameter of microcapsules on the release characteristics were in vestigated.When the ratio of PS to VE(m /m)is 40/1,the permeability coefficie nts were 0.71×10 -9 and 0.74×10 -9 m·s -1 corresponding to the microcapsule diameters of 21.32and 11.45μm,and the concentrations of VE released were 8and 12mg ·L -1 respectively,which conform to the o ptimal concentration in applicatio ns.