原发性肝癌肝移植36例临床分析

Clinical Analysis of 36 Cases of Primary Hepatocellular Carcinoma with Liver Transplantation

目的 探讨原位肝移植在原发性肝癌治疗中的意义。方法 回顾性分析 2 0 0 1年 10月至 2 0 0 3年 8月肝癌肝移植 3 6例的临床病例资料。结果 围手术期死亡率为 0 ;经术前辅助治疗肿瘤直径缩小者 12例 ;术后生存 3～ 6个月者 7例 ( 19.4% ) ,生存 6～ 12个月 10例 ( 2 7.8% ) ,生存 >12个月 19例 ( 5 2 .8% ) ,最长生存 15个月 ,平均生存期为 8.5个月 ,7例晚期肝癌平均生存期4.5月 ,均于术后 3～ 6个月内复发。结论 严格选择肝癌病例并通过术前辅助治疗降低肿瘤分期可提高肝移植效果 ;

Objective To investigate the significance of orthotopic liver transplantation(OLT) in the management of primary hepatocellular carcinoma(PHC).Methods Clinical and following-up data of 36 cases of PHC undertook OLT were analysed retrospectively.Results Perioperational mortality rate was zero;preoperational auxiliary therapy can succeed in reducing the size of tumor in 12 cases,24 cases lives longer than 6 months and 19 cases longer than 12 months,the mean survival span was 8.5 month,while advanced PHCs reoccurred within 3～6 months and the mean survival span was 4.5 month.Conclusion Strict selection of receipts and efficacious auxiliary therapy show a beneficial effect on patient survival;The relation between tumor reoccurrence and postoperational chemotherapy and immunosuppression awaits further study.