黄体酮联合甲基睾丸素治疗未育妇女子宫内膜非典型增生13例分析

Clinical Analysis of 13 Cases of Endometrial Atypical Proliferation in Young Women Treated with Medroxyprogesterone Acetate and Methyltestosterone

目的 探讨黄体酮联合甲基睾丸素治疗未育妇女子宫内膜非典型增生的疗效。方法 对 13例病理诊断为子宫内膜非典型增生要求生育的妇女患者 ,采取黄体酮联合甲基睾丸素治疗 3～ 6个月 ,每 3个月进行诊刮 1次 ,子宫内膜转化为分泌期或萎缩期内膜停药治疗 ,指导受孕。结果 治疗 3、6个月后分别有 11例、12例未育妇女子宫内膜病变逆转为分泌期及萎缩期内膜 ,逆转率分别为 84.6%、92 .3 %。停药 2年内受孕 10例 ,受孕率为 76.9% ,足月分娩 8例 ,流产 2例。随访 2～ 6年 ,复发 2例 ,复发率为 15 .4% ,2例均行手术治疗 ,生存状况良好。

Objective To analysis the recovery,pregnancy and recurrence of endometrial atypical proliferation treated with medroxyprogesterone acetate and methyltestosterone.Methods 13 cases of young women who were diagnosed as endometrial atypical proliferation wanted to be pregnant.They were treated with medroxyprogesterone acetate and methyltestosterone for 3-6months.Dialatation and curettage were performed every 3 months until the endometrium turned to be excretion or atrophy.Then they got pregnant naturally or were treated by drugs of promoting ovulation.Results 11 cases were cured in 3 months and 12 cases in the end of the 6th months.The recovery rate was 84.6% and 92.3%,respectively.The rate of being pregnant was 76.9%(10/13) within 2 years.There were 8 cases of term delivery and 2 cases of abortion.The following-up period was 2～6 years.The recurrence rate was 15.4%(2/13).The 2 relapsed cases were treated with operation.Conclusion Medroxyprogesterone acetate and methyltestosterone were effective to cure endometrial atypical proliferation in young women.