福建省汉族人群HLA-B15组和B40组抗原特异性分布的研究

Antigen Specificity Distribution of HLA-B15 Group and B40 Group in Han Populations of Fujian Province

目的 了解福建省汉族人群 HLA- B1 5组和 B40组抗原特异性的分布情况。方法 采用反相PCR- SSO技术做基因分型 ,并分析各等位基因对应的抗原特异性。结果 1 71名福建省汉族人中 HLA-B1 5基因频率为 0 .1 2 5 7,分属 3种抗原特异性 ,其抗原特异性分布与上海地区人群无显著性差异 ;HLA-B40基因频率为 0 .2 368,分属 3种抗原特异性 ,其抗原特异性分布与上海地区人群存在显著性差异。结论 福建省汉族人群 HLA- B1 5组和 B40组抗原特异性的分布有其自身特点。

Objective To investigate the antigen specificity distribution of HLA-B15 group and B40 group in Han populations of Fujian Province.Methods Defined the genotype of HLA-B by reverse PCR-sequence specific oligo probe method,and antigen specificity each allele belongs to was then analyzed.Results In this study the gene frequency of HLA-B15 was 0.125 7,the alleles belong to 3 kinds of antigen specificity. The gene frequency of HLA-B40 was 0.236 8,the alleles belong to 3 kinds of antigen specificity too.The antigen specificity distribution of HLA-B15 group in studied Fujian populations was similar as that of Shanghai populations,whether in HLA-B40 group the distributions had significant difference between the two populations.Conclusion The results indicate that the antigen specificity distribution of HLA-B15 group and B40 group in Han populations of Fujian province has its special characters.