脑卒中后抑郁的相关因素及氟西汀对抑郁症状的改善作用

Related factors of post-stroke depression and improvement of fluoxetine in depression

目的:探讨致脑卒中后抑郁与病灶部位及神经功能缺损程度的关系并观察氟西汀对抑郁症状的改善作用。方法:用汉密顿抑郁量表(Hamiltonratingscalefordepression,HAMD)对河南省精神病医院住院脑卒中患者110例进行评估,分为抑郁组(48例)和非抑郁组(62例)。观察抑郁与性别、脑卒中性质、病灶部位、神经功能损伤程度的关系。抑郁患者采用口服氟西汀胶囊治疗,以HAMD减分率为疗效评定标准。结果:抑郁的发生与病灶部位、神经功能缺损程度具有显著相关性(P<0.05),氟西汀治疗前后HAMD量表评分减分率比较(治疗前后HAMD平均分分别为24.1±4.9,5.1±3.2),差异有显著性意义(P<0.01)。结论:脑卒中后抑郁与生物因素有肯定的关系,氟西汀能明显改善抑郁症状。

AIM:To study the relationship of depression to focal sites and the severity of neurological impairment and to observe the contribution of fluoxetine to depression.METHODS:Hamilton rating scale for depression(HAMD) was performed in 110 stroke inpatients in the Second Affiliated Hospital of Xinxiang Medical College,including 48 cases of depression(depressive group) and 62 of non-depression(non-depressive group).Correlation of depression with sex,types of stroke,focal sites and the severity of neurological impairment were observed,and HAMD was used to evaluate the curative effect of oral fluoxetine treatment for depressive patients.RESULTS:There was a significant correlation of focal sits and the degree of neurological impairment with the incidence of post-stroke depression(P< 0.05).The HAMD scores were significantly reduced from 24.1±4.9 to 5.1±3.2,showing statistical significance(P< 0.01).CONCLUSION:Post-stroke depression has a significant correlation with biological factors,and fluoxetine can effectively improve depressive status.