急性脑梗死添加弗斯兰治疗对其早期神经功能缺损恢复的影响

Add-on therapy with frozylane for the early rehabilitation of neurological impairment in acute cerebral infarction

目的:观察弗斯兰(活脑灵)添加治疗对急性脑梗死患者早期神经功能缺损康复的影响。方法:将附和入选条件的128例首发脑梗死患者按入院次序依次随机分为两组,每组64例,采用单盲法分别给予基础治疗及基础治疗加用弗斯兰治疗3周。所有患者出院后均随访至治疗后第90天。脑卒中患者临床神经功能缺损评分(CSS)标准于治疗前、治疗后第14,28,90天各评定1次,Barthel指数(BI)于治疗后第28,90天各评定1次。结果:治疗前两组间CSS评分差异无显著性意义(CSS:18.67±8.45比17.78±8.64,t=0.573,P=0.568>0.05),治疗后第14,28天及第90天两组间评分差异有显著性意义(CSS:9.10±6.62,6.49±5.56,4.33±3.51比12.73±8.54,10.33±7.35,7.38±6.06;t=2.618,3.242,3.405;P均<0.05),治疗组均低于对照组。治疗后第28天及治疗后第90天的BI在弗斯兰组亦优于对照组(BI:75.49±23.09,82.30±21.61比61.33±26.29,72.00±21.83;t=3.149,2.607;P均<0.05)。两组急性脑梗死患者用药后综合疗效分析弗斯兰组明显优于对照组(总有效率:91.8%比83.3%;基本控制率:31.1%比18.3%;χ2=8.239,P=0.041<0.05)。结论:弗斯兰添加治疗有利于急性脑梗死患者早期神经功能缺损的康复、患者生活质量的提高及预后的改善。

AIM:To investigate the effect of frozylane as add-on therapy on the early rehabilitation of neurological impairment in the patients with acute cerebral infarction.METHODS:One hundred and twenty-eight patients with firstly acute cerebral infarction were randomly divided into control group and treatment group of 64 cases in each group. Based on the single blind procedure,the patients in the control group received basic therapy,and those in the treatment group were given basic therapy plus flozylane.Ninety-day follow-up was conducted in all the subjects after discharge.Chinese stroke scale(CSS) was used to assess the neurological impairment before and 14,28,90 days after treatment;While Barthel index(BI) was detected 28 and 90 days after treatment.RESULTS:There was no significant difference between the treatment and control groups in the score of CSS before treatment(18.67±8.45 vs 17.78±8.64;t=0.573,P=0.568 >0.05),and there were significant differences 14,28 and 90 days after treatment(9.10±6.62 vs 12.73±8.54,t=2.618,P< 0.05;6.49±5.56 vs 10.33±7.35,t=3.242,P< 0.05;4.33±3.51 vs 7.38±6.06,t=3.405,P< 0.05) and the scores in the control group were all higher than those in the treatment group.BI in the treatment group was 75.49±23.09 and 82.30±21.61 respectively at 28 and 90 days after treatment,both higher than those in the control group(61.33±26.29 and 72.00±21.83)(t=3.149,t=2.607,P< 0.05). The overall efficiency in the treatment group was better as compared with the control group.The total effective rate and basic control rate in the treatment group were 91.8%and 31.1%respectively,superior to those in the control group(83.3%and 18.3%)(χ2=8.239,P=0.041< 0.05).CONCLUSION:The add-on therapy of frozylane is helpful in the early rehabilitation of neurological impairment,promotion of quality of life and improvement of prognosis in acute cerebral infarction patients.