锌和抗氧化剂对年龄相关性黄斑变性患者视功能改善的影响

Effects of zinc and antioxidant on visual function of patients with age-related macular degeneration

目的:研究锌和抗氧化剂对年龄相关性黄斑变性(aged-relatedmaculardegeneration,ARMD)的影响。方法:对早期和中晚期ARMD的患者随机分组,分别口服锌和抗氧化剂与安慰剂,对其预防ARMD进展的效果进行评价比较。结果:联合口服锌和抗氧化剂组抑制中晚期ARMD进展有效率为82.3%,高于对照组72.6%(χ2=4.41,P<0.05);抑制早期ARMD进展有效率为88.2%与对照组82.9%比较差异无统计学意义(χ2=0.85,P>0.05)。结论:锌与抗氧化剂可有效的预防中晚期ARMD的发展,对早期ARMD无预防作用。

AIM:To study the effects of zinc and antioxidants in age-related macular degeneration(ARMD). METHODS:The early and advanced ARMD patients were randomly grouped into oral zinc and antioxidant group and placebo group for a comparative analysis in preventing the severity of ARMD.RESULTS:The effective rate against the severity of advanced ARMD was 82.3%in the oral zinc and antioxidant group,higher than in the placebo group(72.6%)(χ2=4.41,P< 0.05).There was no significant difference in prevention of the early ARMD between the oral zinc and antioxidant group(88.2%) and the placebo group(82.9%)(χ2=0.85,P >0.05).CONCLUSION:Zinc and antioxidants can effectively prevent the advanced ARMD against aggravation, but have no functions to the early ARMD.