偏头痛相关性脑卒中发病中抗磷脂抗体的作用(英文)

Relationship between antiphospholipid antibodies and migraine related cerebral infarction

目的:研究和探讨偏头痛与缺血性卒中的相关性以及抗磷脂抗体在偏头痛相关性卒中发病中的作用。方法:运用问卷调查方式统计普通人群及脑梗死患者偏头痛的患病率,将脑梗死患者按有否偏头痛病史分为两组,用ELISA方法分别测定其血清抗心磷脂抗体(anticardiolipinantibodies,ACA)水平。结果:①脑梗死患者偏头痛的患病率与普通人群偏头痛的患病率分别为20.0%和6.0%,二者之间差异有显著性意义(χ2=13.2671,P<0.01)。②脑梗死伴有偏头痛史者和无偏头痛史者,其ACA阳性率分别为41.7%和19.5%,二者差异具有显著性意义(χ2=5.0133,P<0.05)。结论:偏头痛病史与脑梗死具有明显相关性。抗磷脂抗体可能参与偏头痛所相关的脑梗死的发病机制。

AIM:To study the relationship between migraine and cerebral infarction, and also to explore whether anticardiolipin antibodies(ACA) play a role in the mechanisms of migraine-related cerebral infarction. METHODS:Patients with cerebral infarction and control subjects received a questionnaire that is mainly relative to migraine history.Besides,the patients with cerebral infarction also received sera IgG-ACA detection of enzyme-linked immunoadsordent assay(ELISA). RESULTS:Twenty percent patients had a history of migraine,while only 6.0%of the control subjects had the incidence of migraine.They had statistically significant difference(χ2=13.2671,P< 0.01).The patients with cerebral infarction were divided into two groups:patients with migraine history and patients without migraine history.The positive rates of ACA in the stroke patients with migraine history and that of those without migraine history were 41.67%and 19.5%respectively. They also had statistically significant difference(χ2=5.0133,P< 0.05). CONCLUSION:The study suggested that migraine history was relative to cerebral infarction and ACA might play an important role in the mechanisms of migraine related cerebral infarction.