高脂摄入对大鼠肝血脂及红细胞膜的影响

INFLUENCE OF DIETARY FAT ON LIVER AND SERUM LIPID AS WELL AS ON ERYTHROCYTE MEMBRANE IN RATS

为探讨脂肪酸(FA)对机体肝,血脂及红细胞膜的影响,给Wistar雄性大鼠饲以三种不同饲料35天和63天,三种饲料及动物分组为:23％(w/w)猪油作为饱和脂肪酸(SFA)组,23％(w/w)玉米油作为多不饱和脂肪酸(PUFA)组,5％(w/w)玉米油作为低脂(LFA)对照组。结果发现:大鼠肝脂FA组分可反映摄入脂FA组分;与SFA组相比,PUFA组极低密度脂蛋白胆固醇明显降低,但PUFA组红细胞渗透脆性高、溶血速率快,膜流动性趋于增大;高脂(SFA、PUFA)组大鼠红细胞C_(3b)受体免疫粘附活性降低。本研究表明:高脂尤其是高多不饱和脂对红细胞膜结构及免疫功能有不良影响,既往认为多食用高不饱和脂对机体有利的观点似过于简单化。

To investigate the effects of dietary fatty acids on liver and serum lipid as well as on erythrocyte membrane, 23%(w/w) lard (as saturated fatty acids SFA), 23%(w/w) corn oil (as polyunsaturated fatty acids PUFA) and 5%(w/w) corn oil (as low fatty acids LFA control) were fed respectively to three groups of Wistar rats for 35 and 63 days. The study showed that the pattern of liver fatty acids was correlated with that of dietary fatty acids. Serum VLDL-Ch was lowered in PUFA group when compared with that in SFA group. The osmotic fragility and hemolytic rate of RBC were elevated in PUFA group, but lowered in SFA group. The membrane fluidity of RBC in PUFA group tended to increase. The immune adhesive activity of RBC C3b receptor was impaired when high dietary fat (PUFA, SFA) were given to rats. This study indicates that high dietary fatty acids have adverse effect on RBC membrane structure and immune adhesive function. That high PUFA is good for health is not always correct.