重型急性胰腺炎患者血清甲状腺激素水平的变化及其意义

Significance of measurement of thyroid hormone in severe acute pancreatitis

目的探讨重型急性胰腺炎(SAP)患者血清甲状腺激素含量的动态变化规律及其临床意义。方法用免疫化学发光法测定32例SAP患者的甲状腺激素(TT3、TT4、FT3、FT4和TSH),并与30例健康人作对照。结果SAP组的TT3、FT3、TT4明显低于对照组(P<0.01或<0.05);TT3、FT3在SAP急性期明显下降,而在SAP稳定期明显回升(均P<0.01)。结论血清甲状腺激素含量的测定可作为评估SAP病情严重程度和预后的指标之一。

Objective To study the changes of serum thyroid hormone in severe acute pancreatitis(SAP)and to explore its clinical value.Methods The levels of TT 3 ,FT 3 ,TT 4 ,FT 4 and TSH were measured in32cases of SAP and30healthy subjects by chemiluminescence immunoassay.Results The serum TT 3 ,FT 3 and TT 4 were lower and sig nificantly different in the group with SAP when compared with the healthy group(P<0.01or<0.05).The serum levels of TT 3 and FT 3 of the patients in the acute phase were sig nif i-cantly lower than those of patients in the stable phase of SAP(P<0.01).Conclusion The serum thyroid hormone was helpful in clinical use by judging the severity of the disease and also for prognosis.