锌、铁对机体联合效应的研究

STUDIES ON THE INTERACTION OF ORGANIC ZINC AND HEME IRON IN RATS

选用40只体重在70～110g,SD健康雄性大鼠,随机分为4组。Ⅰ组:低锌低铁组;Ⅱ组:加锌组,加金针菇锌60ppm;Ⅲ组:加铁组,加血红素铁24ppm;Ⅳ组:联合加锌加铁组,加金针菇锌60ppm,血红素铁24ppm。实验35天,结果为Ⅲ、Ⅳ组的Hb、血清铁和肝脏铁明显高于Ⅰ、Ⅱ组,而Ⅱ、Ⅵ组的体重、血清锌、肝脏锌、股骨锌明显高于Ⅰ、Ⅲ组,说明在本次实验条件下,有机锌和血红素铁在机体内未表现出相互拮抗或抑制作用,联合补锌补铁对动物有明显的预防作用。

Forty male weanling rats ( Sprague Dawley strain) were chosen and allotted randomly into four treatments. Diets with various organic zinc and heme iron levels were fed for 35 days respectively. GroupⅠ: the basic diet of low zinc and iron. Group Ⅱ: adding the enokitake zinc to the basic diet in which the organic zinc content was 60 ppm. Group Ⅲ: adding the heme iron to the basic diet in which the heme iron content was 24 ppm. Group Ⅳ: adding the enokitake zinc and heme iron to the basic diet in which the organic zinc and heme iron were 60 ppm, 24ppm respectively. At the end, Hb and the content of serum and hepatic iron in the group Ⅲ, Ⅳ were higher significantly than that in the group Ⅰ, Ⅱ.The body weight, serum zinc, hepatic zinc and femur zinc in group Ⅱ, Ⅳ were higher significantly than that in group Ⅰ,Ⅲ. It suggests that there isn't competitive inhibitory interaction between the organic zinc and the heme iron and combined supplementation of them can prevent from zinc and iron deficiency.