灯盏花素治疗2型糖尿病患者周围神经病初步观察

Preliminary clinical observations of brevisapin on type 2 diabetic polyneuropathy

目的 观察灯盏花素注射液治疗 2型糖尿病周围神经病变的疗效。方法 3 7例 2型糖尿病周围神经病 ,每天 1次静滴灯盏花素 90mg ,连用 2周 ;对照组 3 0例 ,每天 1次静滴胞二磷胆碱 0 5g ,连用 2周。观察两组病人治疗前后的肢体持续性疼痛、麻木的程度 ;拇趾振动觉、踝反射、膝反射、皮肤触痛等。结果 治疗组肢体麻木、疼痛、皮肤触痛消失或缓解 ,拇趾振动觉、踝反射恢复总有效率 96%,而对照组 5 3 %,未发现明显不良反应。结论 灯盏花素治疗

Objective To investigate the effect of brevisapin on diabetic poluneuropathy.Methods Sixty seven patients with diabetic polyneuropathy were involved in a randomized positive-control clinical trial.37 cases were treated with brevisapin injection solusion 20 ml(contaning total flavone 90mg) intravenous infusion darly for 2 weeks;30 cases were treated with cytidine diphosphate choline in same way and served as controls.All patients were also administered VitB6,nimodipine at the same time and the original diabetic treatments were carred on.All patients' limb spontaneous pain,limb numbness,great toe vibrative sense,ankle reflection,major common peroneal nerve conduction velocity were evaluated in pre and post therapy by tow neuropathic attending physicians.Results Spontaneous pain and numbness of limb were improved by 96% and 97% in brevisapin group,which were much higher than those in controls(56% and 60% respectively),Great toe vibrative sence,ankle reflction, major common peroneal nerve conduction velocity showed better respone in brevisapin group than in controls (95% vs 47%,93% vs 52%,86% vs 20% respectively).Brevisapin also benefited limb coldness, constipation and vision illness to a centain extent. No obvious side effects were found.Conclusion Brevisapin is worthy of use as a safe effective agent in the treatment of diabetic polyneuropathy.