维生素E和C对肺癌介入化疗患者血浆LPO及红细胞SOD水平的影响

EFFECT OF INSERTIONAL CHEMOTHERAPY WITH VITAMIN E AND VITAMIN C ON THE LEVELS OF PLASMA LPO AND RBC SOD IN PULMONARY CANCER PATIENTS

观察了20例使用和19例未使用维生素E(VE)和维生素C(VC)的肺癌患者在介入化学疗法(支气管动脉内药物注射)前后血浆LPD(过氧化脂质,lipid peroxide)和红细胞SOD(超氧化物歧化酶;superoxide dismutase)水平的变化,结果:1)未使用VE、VC的肺癌患者在介入化学疗法后血浆LPO水平明显上升(P<0.02)、红细胞SOD水平显著下降(P<0.01);2)使用VE、VC的患者在介入化学疗法后血浆LPO明显下降(P<0.05),红细胞SOD水平上升,但差异无显著性(P>0.05);3)血浆LPO水平和VC摄入量之间有明显负相关,r=-0.55(P<0.01),而和VE间无明显负相关,r=-0.02(P>0.05)。

The change of plasma lipid peroxide (LPO) and RBC superoxide dismutase (SOD) in 39 cases of pulmonary cancer, amongst them 20 cases with and 19 cases without supplementation of vitamin E and vitamin C, before and after the insertional chemotherapy in the brachial artery were observed. The results showed. (l)The level of plasma LPO was elevated (P<0.02) and RBC SOD was reduced (P<0.01) if the pulmonary cancer patients were given insertional chemotherapy without vitamin E and vitamin C; (2) The level of plasma LPO was reduced (P<0.05) and RBC SOD tended to rise but not significantly different after the insertional chemotherapy with vitamin E and vitamin C; (3) The level of plasma LPO was negatively correlated with the intake of vitamin C(r = -0.55, p<0.01), but not with vitamin E (r= -0.22, P>05).