舒肝丸治疗胃脘痛的实验研究

Experimental study on treatment of epigastralgia with Shugan Pills

目的 :研究舒肝丸 (川楝子 ,延胡索 ,白芍 ,木香 ,厚朴 ,枳壳等 )治疗胃脘痛的作用。方法 :以热板法和扭体法观察其镇痛作用 ;以小鼠水浸应激性、利血平性及无水乙醇性胃溃疡模型观察舒肝丸对胃溃疡的保护作用 ;幽门结扎收集胃液 ,观察其对胃液分泌的影响 ;以小鼠胃排空及小肠推进方法观察舒肝丸对胃肠运动的影响。结果 :舒肝丸可提高小鼠的热痛阈 ,减少小鼠的扭体次数 ;对小鼠水浸应激性、利血平性及无水乙醇性胃溃疡模型均有明显的保护作用 ;能抑制大鼠胃酸及胃蛋白酶的分泌 ,促进胃黏液的分泌 ;舒肝丸能抑制正常小鼠胃排空及新斯的明所致的胃排空和肠推进亢进 ,对阿托品所致的胃排空肠推进迟缓有协同作用 ,但不明显。结论 :舒肝丸具有镇痛、抗胃溃疡、抑制胃酸分泌及胃平滑肌运动等作用。这些作用是其治疗胃脘痛的药理学基础。

AIM: To study the action of Shugan Pills (SHGP) (Fructus Toosendan, Rhizoma corydalis, Radix Paloniae Albe, Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Aurantii, etc.) on treatment of epigastralgia. METHODS: The analgesic effect was tested by the hot plate test and writhing method. The anti gastric ulcer action of SHGP was observed on the gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. The effect on gastric secretion in rats was studied with pylorus ligation. The effect on gastrointestinal motility was observed by determination of gastric emptying and small intestinal propulsion ability in mouse. RESULTS: SHGP enhanced hot pain threhshold and decreased the number of twisting body in mouse. SHGP markedly inhibited gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. SHGP significantly inhibited the secretion of gastric acid and pepsin and promoted the secretion of gastric mucus. SHGP markedly delayed gastric emptying in normal mouse and when gastric emptying and small intestinal propulsion was stimulated by neostigmine. SHGP faintly strengthed the effect of atropine on inhibition of gastrointestinal motility. CONCLUSION: Shugan Pills could have analgesic effect, anti gastric ulcer action, it inhibited the secrection of gastric juice and the activity of gastric smooth muscle. These effects might be the pharmacological mechanisms of SHGP on treatment of epigastralgia.