中医药治疗对糖尿病早期肾损害病人β_2-MG、α_1-MG、uAlb水平的影响

Effect of Chinese Medicine Treatment on β_2-MG, α_1-MG and uAlb Level in the Patients of Early Renal Lesion due to Diabetes

目的 探讨益气补肾化瘀治疗加用祛浊治疗对糖尿病早期肾损害病人血、尿 β2 -微球蛋白( β2 -MG )、α1-微球蛋白 (α1-MG)及尿微量白蛋白 (uAlb)水平的影响。方法 将 6 0例观察病人随机分为祛浊益气补肾化瘀组(治疗组 ) 3 0例、益气补肾化瘀组(对照组 ) 3 0例 ,两组疗程均为 6 0d ,疗程结束后评定疗效。结果 治疗后治疗组、对照组与治疗前比较 :空腹血糖、尿 β2 -MG、尿α1-MG、uAlb均有统计学意义(P <0 .0 1或P <0 .0 5 ) ;治疗组与对照组治疗后比较 ,尿α1-MG有显著差异 (P <0 .0 1)。结论 祛浊益气补肾化瘀治疗可降低血糖 ,改善糖尿病早期肾损害 ,显著降低尿α1-MG水平。

Objective To explore the effect of the principle for supplementing Qi, tonifying the kidney and removing blood stasis, and plus expelling turbid on β 2-MG, α 1-MG and uAlb level in the patients of early renal lesion due to diabetes. Methods 60 cases were randomly divided into the treatment group with expelling turbid, supplementing Qi, tonifying the kidney and removing blood stasis(30 cases); and the control group with supplementing Qi, tonifying the kidney and removing blood stasis(30 cases). Each course was 60 days. Results After treatment the fasting blood glucose, urine level of β 2-MG, α 1-MG and uAlb were significant lower in both groups(P<0.01～P<0.05); urine level of α1-MG was significant difference between the two groups(P<0.01). Conclusion Principle for supplementing Qi, tonifying the kidney and removing blood stasis are the action of lowering blood glucose level and decreasing early renal lesion; the plus treatment of expelling turbid is markedly to lower uAlb level.