96h吸^(131)I率在放射性^(131)I治疗Graves病中的应用

Short term curative effect of ^(131)I with 96 h uptake ratio on Graves' disease

目的 评价 96h吸13 1I率在Graves病放射性13 1I治疗中的临床价值。方法 16 0例Graves病13 1I治疗患者随机分为两组 ,A组 6 4例用Quimby公式计算治疗剂量 ,B组 96例用 96h吸13 1I率计算治疗剂量 ;13 1I治疗后随访 9个月～ 1年 ;做出疗效判断并比较分析。结果 ①A、B组及其不同疗效间甲状腺重量、服13 1I量比较无显著性差异 (P >0 0 5 )。②A组痊愈、好转、无效、甲低的百分数分别为 2 8 13%、4 0 6 3%、0 %及 31 2 5 % ;B组为 31 2 5 %、4 8 96 %、1 0 4 %及 18 75 %。③不同甲状腺重量及年龄的甲低发生率比较无统计学意义。④病程≤ 6个月的患者 ,甲低发生率为 37 78% ,其中A、B组分别为 4 3 4 8%及31 82 %。结论 可以利用 96h吸13 1I率代替复杂的Quimby公式来计算Graves病13

Objective To evaluate the therapeutic effect of 131 I on Graves' disease with 96 h uptake.Methods Patients with Graves disease (n=160) were divided into two groups.For group A (n=64) Quimby formula was used to calculate the dose, and for group B(n=96) 96 h uptake ratio was used to calculate the dose. Their short term curative effect was compared after 9 months or 1 year. Results ① There was no significant difference in the weight of thyroid and the age of patients in both groups (P>0.05). ②Percent rates of cure, improvement, inefficacy and hypothyroidism in group A were 28 13%,40 63%,0% and 31 25% respectively,while which were 31 25%,48 96%,1 04% and 18.75% in group B. ③There was no significant difference in the hypothyroidism incidence in different thyroid weight and patient age. ④The total incidence of hypothyroidism was 37.78% when the medical history was shorter than 6 months. The incidence rate of hypothyroidism in patients with disease history shorter than 6 months was 43 48% in group A and 31 82% in group B.Conclusion The use of 96 h thyroid uptake ratio can be as a replacement method for Quimby formula to calculate the 131 I dosage.