3-甲基-4-苯基-1,2,4-三唑-5-酮合成的研究

A study on the synthesis of 3-methyl-4-phenyl-1,2,4-triazol-5-one

目的 研究3 甲基 4 苯基 1,2,4 三唑 5 酮合成的新方法。方法 以三氯氧磷为缩合剂,在110℃反应3h,用碱中和后,分离中间产物,再进行环化反应。结果 两步反应总产率74.3%,比相关文献报道值,高出30%,并对目标物质进行了分析鉴定和表征。结论 反应条件温和,产率高,具有较好的应用前景。

Aim3-methyl-4-phenyl-1,2,4-triazol-5-one was prepared by the reaction of N-phenyl acetamide with ethyl hydrozino-formate .Methods At 110℃ for three hours in the presence of POCl_3 , following neutralization and cyclization reaction.ResultsGiving a 74.3% yield(in total) of title compound which are 30% more than literature report . The title compound was characterized by HNMR, IR and elementary analysis.ConclusionThe method of preparation of 1,2,4-triazolone derivative is more available with mild reaction condition and good yield.