经皮渗透促进剂卡必醇的应用和机制

Application and mechanism of Transcutol as enhancer for percutaneous absorption

目的 介绍卡必醇近年来国内外在经皮给药制剂中的研究和应用。方法 分析有关文献资料 ,对卡必醇的理化性质 ,以及卡必醇在经皮促渗方面的应用和机制进行总结归纳。结果和结论 卡必醇作为一种优良的渗透促进剂 ,具有广泛的应用前景。

OBJECTIVE To summarize various recent studies and application of transcutol on transdermal drug delivery system. METHOD Based on the results of this subject from the related literatures, the physico-chemical characteristics of transcutol, the application and the mechanism of transcutol on enhancement of percutaneous penetration were summarized and evaluated.RESULTS AND CONCLUSION Transcutol has wide prospects of application as a good penetration enhancer.