摘要
目的 考察盐酸消旋山莨菪碱注射液 (下称 6 5 4 2 )与临床常用氨基糖苷类抗生素在 5 %葡萄糖 (下称 5 %GS)中的配伍稳定性。方法 观察配伍液外观、测定配伍液 pH、紫外吸收光谱和 6 5 4 2含量变化 ,并进行薄层分析。 结果 30℃时 ,6 5 4 2与庆大霉素、妥布霉素、小诺霉素、丁胺卡那霉素等注射液 (下称庆大、妥布、小诺、丁卡 )配伍后 6h内外观不变、pH值未见明显改变、紫外吸收光谱几无改变 ,与妥布、庆大配伍 6h内 ,6 5 4 2含量维持在初始浓度 92 %以上 ,与小诺、丁卡配伍 1~ 1.5h后 ,含量即降至初始浓度的 90 %以下 ,薄层色谱未见杂斑生成。结论 6 5 4 2可与妥布、庆大配伍使用 ,避免与小诺、丁卡配伍。
OBJECTIVE To study the stability of raceanisodamine hydrochloride injection mixed with four aminoglycoside antibiotics in 5% glucose injection solution. METHOD Investigate the appearance, pH, UV spectrum and the content of 654-2 of mixtures.TLC analysis was also been used.RESULTS The mixed solution had no significant changes in the appearance, pH, UV spectrum at 30℃ within 6h.The content of 654-2 retained more than 92% of its initial level within 6h when mixed with tobramicin and gentamycin, but less than 90% when mixed with micronomicin and amicacin after 1~1.5h. New substance was not been found by TLC.CONCLUSION The compatibility of 654-2 with tobramicin, gentamicin is feasible, however is not in steady-state when it mixed with micronomicin and amicacin.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第1期71-72,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
山莨菪碱
氨基糖苷类抗生素
配伍
稳定性
raceanisodamine hydrochloride
aminoglycoside antibiotics
compatibility
stability