早期应用硫酸镁治疗急性颅脑损伤临床效果分析

Clinical effect of early applied Magnesium sulfate on acute craniocerebral trauma

目的 评价早期应用硫酸镁对急性颅脑损伤的疗效。方法 选择我科自 2 0 0 2年 1月～ 2 0 0 3年 1月收治的急性颅脑损伤病人 10 5例为研究对象 ,均无合并伤及并发症 ,随机分成治疗组和对照组 ,通过不同时期GCS、死亡率及伤后半年GOS为指标进行比较。结果 治疗第 5天及 1月时的GCS分别为 10 .1± 2 .2、13 .5± 2 .4,与对照组7.6± 2 .4、10 .8± 1.0比较有非常显著差异 (P <0 .0 1)。 5天、1月、半年死亡率 ,治疗组分别为 2 / 5 5 ( 3 .64 % )、3 / 5 5 ( 5 .45 % )、4/ 5 5 ( 7.2 7% ) ,与对照组 8/ 5 0 ( 16% )、9/ 5 0 ( 18% )、12 / 5 0 ( 2 4% )比较有显著差异 (P <0 .0 5 )。随访半年GOS预后评分 ,治疗组Ⅰ级 3 5例、Ⅱ级 11例、Ⅲ级 4例、Ⅳ级 1例、死亡 4例 ,对照组分别为 15例、10例、10例、3例、12例 ,两者比较有非常显著差异 (P <0 .0 1)。结论 早期应用硫酸镁能明显降低颅脑损伤的死亡率 。

Objective To study the clinical effect of early applied magnesium sulfate on acute craniocerebral trauma.Methods One hundred and five patients with acute craniocerebral trauma hospitalized in our hospital from January 2002 to January 2003 were randomly divided into the treatment group(n=55)and the control group(n=50).Gcs,death rate and Gos were observed.Results The GCS and GOS of the treatment group were higher than those of the control group.(P<0.01)Compared with the control group,the death rate of the treatment group were found to be obviously decreasing at 5days,lmonth and half a year (P<0.05).Conclusions Early applied magnesium sulfate on acute craniocerebral trauma could significantly decrease the death rate and improve nerval function and prognosis.