人肺癌组织多药耐药基因的探讨

Analysis of multi-drug resistance genes in human lung cancer

本文采用 RT- PCR方法检测了 38例 NSCL C肿瘤组织 ,10例良性瘤样病变和 35例病灶旁正常肺组织中 mdr1基因的表达水平。结果表明 ,肺癌组织中 mdr1m RNA过度表达 ,因此推测 m

Objective:To study drug resistance in human lung tumors with the reverse transcription polymerase chain reaction (RT-PCR) ,the expression leve1 of mdr1 gene was evaluated in 38 NSCLC tumor samples, 10 benign phymatoid lesion and 35 adjacent normal lung tissue samples. Results: The expression of mdr1 gene was higher in lung cancer. Conclusion:The expression of mdr1 gene is considered to be an important mechanism involved in drug resistance in human lung tumors.