阑尾炎史与结直肠癌发病关系的研究

A Retrospective Cohort Study on the Association between Colorectal Cancer and History of Appendicitis

目的 研究阑尾炎与结直肠癌发病之间的关系。方法 以 1989年 5月至 1990年 4月期间 ,参加浙江省嘉善县大肠癌筛查的 10个乡镇 3 0岁及以上人口为研究队列 ,按是否具有阑尾炎史分为暴露组和非暴露组 ,随访从 1990年 5月至 2 0 0 1年 1月 ,应用回顾性队列研究的方法 ,对结直肠癌发病率进行分析 ,并作相对危险度 (RR)估计。结果 Poisson回归分析表明 ,经控制年龄因素后 ,阑尾炎史仅在女性结肠癌中表现出有统计学意义 (P <0 0 5 ) ,有阑尾炎史者结肠癌的发病风险较之无阑尾炎史者高达近 2倍 ,RR为 1 93 3 5 ,95 %可信限为 1 0 45 6～ 3 5 75 4。结论 阑尾炎史与结肠癌的发病有关 ,阑尾炎史是结肠癌的重要危险因子。

Objective In order to identify the association between colorectal cancer (CRC) and history of appendicitis.Methods Based on the cohort established by the screening for CRC among 64693 residents aged 30 and over 30 years old in 10 villages and towns in Jiashan County of China from May.1989 to April.1990, the cohort were followed-up from May.1990 to January.2001 for the CRC occurrence.The CRC incidence rate was compared between two groups differentiated by the history of appendicitis, and RR was estimated by controlling age. Results By the Poisson regression analysis with confounding effect of age controued,there was statistical significant difference only in female colonic cancer between exposure and non-exposure groups with RR,1.9335;and 95%CI,1.0456-3.5754. Conclusions The history of appendicitis associates with colonic cancer, which may be an important risk factor for colonic cancer in female.