结缔组织生长因子与硬皮病关系的研究进展
摘要
硬皮病病因不清 ,由转化生长因子 β诱导产生的结缔组织生长因子在其发病机制中起重要作用。结缔组织生长因子可通过整合素介导的信号途径 ,使成纤维细胞获得趋化活性及有丝分裂活性 ,导致胶原合成增多 ,并与动脉内膜增殖及血栓形成相关。结缔组织生长因子表达的调控与其启动子上的Smad结合位点及转化生长因子
出处
《国外医学（皮肤性病学分册）》
2004年第2期88-90,共3页
Foreign Medical Sciences(Section of Dermatology and Venereology)
参考文献42
-
1Ihn H. The role of TGF-beta signaling in the pathogenesis of fibrosis in scleroderma. Arch Immunol Ther Exp ( Warsz), 2002, 50 ( 5 ) :325 - 331.
-
2Brigstock DR, Goldschmeding R, Katsube KI, et al. Proposal for a unified CCN nomenclature. Mol Pathol, 2003, 56(2) : 127 - 128.
-
3Brig'stock DR. The connective tissue growth factor/cysteine-fich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev, 1999, 20(2) :189 -206.
-
4Bradham DM, Igarashi A, Potter RL, et al. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol, 1991, 114(6) :1285 - 1294.
-
5Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ, 1996, 7(4) :469.
-
6Frazier K, Williams S, Kothapalli D, et al. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol, 1996, 107 (3) :404 - 411.
-
7Grotendorst GR. Connective tissue growth factor: a mediator of TGFbeta action on fibroblasts. Cytokine Growth Factor Rev, 1997, 8 (3) :171 -179.
-
8Duncan MR, Frazier KS, Abramson S, et al. Connective tissue growthfactor mediates transforming growth factor beta-induced collagen syn-thesis: down-regulation by cAMP. FASEB J, 1999, 13(13) :17746.
-
9Querfeld C, Eckes B, Huerkamp C, et al. Expression of TGF-beta 1,- beta 2 and-beta 3 in localized and systemic scleroderma. J Dermatol Sci, 1999, 21 ( 1 ) : 13 - 22.
-
10Igamshi A, Nashiro K, Kikuchi K, et al. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J InvestDermatol, 1995. 105(2) :280 -284.
-
1李晓阳.I—8其在呼吸系统疾病中的作用[J].怀化医专学报,2002,1(2):71-73.
-
2孙凌云.趋化因子在风湿病中的研究进展[J].中华风湿病学杂志,2003,7(12):755-758.
-
3韩书芝,平芬,李贤,赵景春,张冬会.单核细胞趋化蛋白-1与慢性阻塞性肺疾病相关性研究[J].中国老年学杂志,2007,27(9):891-892. 被引量：2
-
4朱春晖,冼苏.结缔组织生长因子与糖尿病慢性并发症[J].医学文选,2004,23(2):194-196.
-
5王铭,张艳,张溪媛,庞敏.益气活血复方对动脉粥样硬化家兔VCAM-1表达的影响[J].实用中医内科杂志,2009,23(5):39-40.
-
6舒平.中性粒细胞在细菌性肺炎中的作用[J].友谊医刊,1998,21(3):83-83.
-
7阳显慧,李国秀,吴雨平,施焕中,汤斌.慢性阻塞性肺疾病患者血清白细胞介素-8水平的变化[J].中国老年学杂志,1997,17(6):368-369.
-
8张彦亮,杨大明,孟宪镛.结缔组织生长因子与肝纤维化[J].国外医学（内科学分册）,2002,29(6):255-257.
-
9刘会武,张艳,孙江波.益气活血复方对兔颈总动脉球囊损伤后基质金属蛋白酶-2mRNA表达的影响[J].中国康复理论与实践,2009,15(1):41-43.
-
10朱雪娟,周国雄.单核细胞趋化蛋白-1与胰腺炎关系的研究进展[J].国际内科学杂志,2007,34(12):708-711. 被引量：1
