丝蛋白纤维生物材料与组织工程

SILK PROTEIN FIBER BIOMATERIALS AND TISSUE ENGINEERING

目的 介绍并综合分析丝蛋白纤维生物材料的研究进展及其在组织工程中的应用。 方法 广泛查阅国外近期关于丝蛋白纤维生物材料的研究文献 ,着重分析丝蛋白纤维生物材料的特性及可能的应用。 结果 丝蛋白纤维不仅与天然胶原一样起支持细胞黏附、分化和生长的作用 ,而且是生物相容性良好的、具有独特机械特性并能在较长时间内缓慢降解的一类新型生物材料。 结论 丝蛋白纤维生物材料可以作为体外细胞培养的合适基质 ,并在组织工程中有广泛的应用前景。

Objective To summarize the latest developments in silk protein fiber as biomaterials and their applications in tissue engineering. Methods Recent original literature on silk protein fiber as biomaterials were reviewed, illustrating the properties of silk protein fiber biomaterials. Results The silk protein fiber has the same functions of supporting the cell adhesion, differentiation and growth as native collagen, and is renewed as novel biomaterials with good biocompatibility, unique mechanical properties and is degradable over a longer time. Conclusion Silk protein fiber can be used as a suitable matrix for three dimensional cell culture in tissue engineering. It has a great potential applications in other fields.