佳苏仑用于拮抗全麻后的呼吸抑制

Antagonist Gesuline Applied on Respiratory inhibition after General Anesthesia

目的 观察佳苏仑拮抗全麻后呼吸抑制的效果。方法 30例全麻病人术后意识未恢复 ,防御反射差 ,潮气量低于正常值 ,静脉注射佳苏仑 1 5mg/kg ,观察注射后 5min、10min的潮气量、呼吸频率、心率及平均动脉压。结果 潮气量、呼吸频率与注药前相比迅速增加 (P <0 0 1) ,血压、心率与注药前相比无显著差异 (P >0 0 5 )。结论 佳苏仑用于拮抗全麻后的呼吸抑制有效而安全。

Objective To observe the effect of respiratory inhibition by gesuline after general anesthesia. Methods 30 cases of general anesthesia patient unconscious, low reaction and tidal volume were injected 1.5mg/kg and observe the R, HR and MAP after 5 and 10 min. Results The tidal volume, R were rapidly increased (P<0.01) but without Bp and HR changes than control group. Conclusion Gesuline might be effective and safe used as antagonist after general anesthesia.