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预处理的迟发性保护作用 被引量：2

The delayed protection following preconditioning
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摘要 缺血预处理诱发迟发性保护作用发生于预处理后 2 4～ 72 h。腺苷和 NO可能是两种独立的保护作用启动因子。通过激活 PKC酶、酪氨酸激酶和 p38MAP酶 ,促使 HSP 2 7、Mn- SOD等蛋白合成及磷酸化 ,最终发生迟发性保护效应。 KATP是缺血预处理迟发性保护作用的重要中心环节 。 The delayed protection evoked by ischemia preconditioning occured in 24～72 hours after preconditioning. Adenosine and NO appeared to be independent triggers of the delayed preconditioning response. The phosphorylation of HSP 27 and Mn SOD was likely to induce the delayed protective response through the PKC, tyrosine kinases and p38 MAP kinase activation. Although many studies suggested pivotal involvement of K ATP channel opening during the index ischemic insult, it's not known about related mechanism.
作者 高京生 郑业华 罗成基
机构地区 第三军医大学预防医学系全军复合伤研究所 广州空军
出处 《疾病控制杂志》 2003年第4期335-337,共3页 Chinese Journal of Disease Control and Prevention
关键词 预处理 迟发性保护作用 缺血预处理 一氧化氮 再灌流损伤 腺苷学说 酪氨酸激酶 ischemic preconditioning nitric oxide research
分类号 R364.12 [医药卫生—病理学]
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参考文献21

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同被引文献15

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  • 3Sainani GS.Non-drug therapy in prevention and control of hypertension.J Assoc Physicians India 2003;51:1001-6
  • 4Labarthe D,Ayala C.Nondrug interventions in hypertension prevention and control.Cardiol Clin 2002; 20(2):249-63
  • 5Yamashita H,Tsukayama H,Sugishita C.Popularity of complementary and alternative medicine in Japan:a survey.Complement Ther Med 2002; 10(2):84-93
  • 6Alraek T,Soedal LI,Fagerheim SU,et al.Acupuncture treatment in the prevention of uncomplicated recurrent lower urinary tract infections in adult women.Am J Public Health 2002; 92(10):1609-11
  • 7Knoblach SM, Faden AI. Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol 1998;153(1):143-51.
  • 8Asahara H, Asanuma M, Ogawa N,et al. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis.Biochem Mol Biol Int 1995;37(5):827-32.
  • 9Baldwin AS Jr.Series introduction:the transcription factor NF-kappaB and human disease.J Clin Invest 2001;107(1):3-6.
  • 10易受乡,林亚平,严洁,常小荣,杨昱,田岳风.针刺内关与缺血预处理对心肌缺血再灌注损伤保护作用的比较[J].中国中医基础医学杂志,2001,7(8):56-58. 被引量：34

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疾病控制杂志
2003年 第4期

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