14例亚急性皮肤型红斑狼疮临床分析及中医、中西医结合治疗

Clinical Analysis of 14 Cases of Subacute Cutaneous Lupus Erythematosus and Treatment with Tradi tional Chi-nese Medicine or Integrated Traditional Chinese and Western Medicine

目的观察亚急性皮肤型红斑狼疮(SCLE)的临床特征和中药治疗、中西医结合治疗的效果。方法对SCLE的临床表现和实验室检查进行分析;所有病例予青凌草方治疗,若皮疹多,合用羟氯喹或少量皮质类固醇。3个月后评价治疗效果。结果SCLE的光敏感发生率高(57.14%),抗Ro抗体阳性率高(64.29%),而较少合并内脏损害。经3个月治疗,临床缓解率35.71%,显效率28.57%,有效率21.43%,无效率14.29%。结论SCLE有鲜明的临床特征;青凌草方对SCLE有较好的治疗效果。

Objective To investigate the clinical characteristics of subacute cutaneous lupus erythematosus(SCLE)and observe effecacy treated by traditional Chinese medicine or integrated traditional Chinese and Western medicine.Meth ods The clinical and laboratory findings of14patients with SCLE were analyzed.9cases were treated with Qin-glingcao Formula(QLCF,a formula of Chinese herbs),3cases with QLCF and hydroxychloroquine,2cases with QLCF and prednisone.Results Photosensitivity was prevalent in SCLE patients,high ratio of positive anti-SSA/Ro antibody was observed,but systemic manifestations were mild.After3months of treatment,clinical cure rate was35.71%,marked improvement rate was28.57%,improvement rate was21.43%,and no improvement rate was14.29%.Conclu sions SCLE has remarkable clinical features.QLCF has good effects on SCLE treatment.