Ang2基因表达与胃癌发生发展的关系

Study on the Correlation between Expression of Angiopoietin-2(Ang2)and Carcinogenesis,Progression of Gastric Cancer

观察Ang2基因表达与胃癌发生、进展的关系。方法:应用原位杂交方法检测10例正常粘膜、26例早期胃癌、30例进展期胃癌中Ang2mRNA表达。结果:早期胃癌中Ang2mRNA表达阳性率显著高于正常粘膜的阳性率(P<0.05),进展期胃癌Ang2mRNA表达的阳性率显著高于早期胃癌的阳性率(P<0.01);低分化、未分化胃癌中Ang2mRNA阳性率显著高于高、中分化胃癌(P<0.01)。结论:Ang2基因在胃癌的发生、发展中发挥重要作用,可用作胃癌抗血管治疗的靶标。

Objective:To study the correlation between expression of Ang2and carcino-genesis,progression of gastric cancer.Methods:The expression of Ang2mRNA was detected with in situ hybridization in10cases of normal mucosa,26cases of early gastric cancer and30cases of progressive gastric cancer.Results:The Positive rate of Ang2mRNA in early gastric cancer was significantly higher than that in normal mucosa;The positive rate of Ang2mRNA in progres-sive gastric cancer was significantly higher than that in early gastric cancer.The positive rates of Ang2mRNA in poorly differentiated and undifferentiated gastric cancer were significantly higher than that in well differentiated and moderately differentiated gastric cancer.Conclusion:Ang2gene palys an important role in the carcinogenesis and progression of gastric cancer,and it can be used as a target for the therapy of anti-angiogenesis in gastric cancer.