外阴血管肌纤维母细胞瘤

Vulvar Angiomyofibroblastoma

探讨血管肌纤维母细胞瘤的临床病理形态特点及鉴别诊断。方法:对5例血管肌纤维母细胞瘤进行病理组织学,免疫组织化学研究。结果:血管肌纤维母细胞瘤,瘤细胞分布于粘液样背景中,瘤细胞分布疏密不一,构成多细胞密集区与少细胞疏松区,瘤细胞呈短梭形、星状、上皮样。多细胞区瘤细胞呈束状围绕在血管周围,间质有丰富的薄壁小血管或毛细血管。免疫组织化学显示4例Vimentin、Desmin阳性,3例SMA阳性,S-100和CD34均阴性。结论:血管肌纤维母细胞瘤为软组织粘液性肿瘤,好发于女性生殖道,起源于肌纤维母细胞或纤维母细胞,其诊断与鉴别诊断主要依靠病理组织学及免疫组织化学。

Objective:To investigate the clinicopathologic features of angiomyofibroblastoma and it's differential diagnosis.Methods:Four cases of angiomyofibroblastoma were studied by histopathological and immunohistochemical analysis.Results:Angiomyofibroblastoma,embeddes in myxoid background,was characterized by alternating hypercellular and hypocellular areas.The tu-mor was composed of short spindled,stellate-shaped and epithelioid cells.In the hypercellular areas with abundant thin-walled blood vessles,the tumor cells were concentrated around the vessles.Immunohistochemically,the tumor expressed vimentin and desmin(4of3cases),SMA(30f 3cases).No immunoreactivity was detected for S-100and CD34.Conclusion:Angiomyofibroblas-toma,a distinct myxoid tumor of soft tissue,frequently located in the female genital tract,origi-nated from myofibroblasts or fibroblasts.The diagnosis and differential diagnosis of angiomyofi-broblastoma mainly relies on histopathological and immunohistochmical findings.