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用PKC抑制剂Rottlerin治疗小鼠实验性哮喘的研究 被引量：1

Potential in for PKC inhibitor Rottlerin in murine experimental model of asthma
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摘要 目的　研究蛋白激酶PKC抑制剂Rottlerin在防治小鼠实验性哮喘中的作用。方法　OVA蛋白诱导BALB/c小鼠建立实验性气道哮喘模型。腹腔注射给予PKC抑制剂Rottlerin与PBS ,比较肺抗性及气道反应 ,肺组织学和Th2 细胞因子产生的差异。结果　腹腔注射Rottlerin ( 0 .3mg/kg)可抑制肺支气管AHR及嗜酸性粒细胞浸润 ,阻止气道组织嗜酸粒细胞炎症 ,Goblet细胞增生及粘液产生 ,明显减弱血清中IgE及Th2 细胞因子的产生。结论　腹腔注射PKC抑制剂Rott Objective To study the potential role of PKC inhibitor Rottlerin in the treatment of asthma. Methods Balb/c mice were sensitized and challenged with ovalbumin(OVA) protein to construct murine experimental model of asthma. Then the mice were treated by means of injection of Rottlerin or phosphate buffered saline (PBS) into the abdominal cavity. Changes of the total serum IgE, pulmonary eosinophils, cytokines and pulmonary inflammation were investigated. Results Injection of Rottlerin at the dose 0.3 mg/kg into the murine abdominal cavity could inhibit the infiltration of pulmonary eosinophils and pulmonary inflammation and significantly decrease the production of total serum IgE and Th 2 cytokines as well. Conclusion Rottlerin can inhibit murine experimental asthma.
作者 宋建勇 任渝祥 林辉 张晓民 宋建勋
机构地区 第三军医大学预防医学系流行病学教研室 第三军医大学基础医学部全军免疫学研究所
出处 《第三军医大学学报》 CAS CSCD 北大核心 2003年第16期1411-1414,共4页 Journal of Third Military Medical University
基金 国家自然科学基金资助项目 ( 30 2 0 1812 )
关键词 哮喘 PKC 抑制剂 变态反应 炎症 细胞因子 ROTTLERIN 治疗 asthma PKC inhibitor allergy inflammation cytokine
分类号 R562.25 [医药卫生—呼吸系统] R392.11 [医药卫生—免疫学]
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参考文献14

  • 1Sandford A;Pare P.Homing in on the asthma gene,2002(9331).
  • 2Pernis AB;Rothman PB.JAK-STAT signaling in asthma,2002.
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  • 4San Antonio B;Iniguez M A;Fresno M.Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity[J],2002(30).
  • 5Kayali A G;Austin D A;Webster N J.Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation[J],2002(10).
  • 6Chen JH;Huang CH;Lin L Y.Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells[J],2001(03).
  • 7Huang J;Lo P F;Zal T.CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse[J],2002(14).
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同被引文献7

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  • 7周林福,殷凯生.小剂量三氧化二砷对哮喘豚鼠气道嗜酸细胞凋亡和核因子κB表达作用的相关性研究[J].中华结核和呼吸杂志,2002,25(7):439-439. 被引量：20

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第三军医大学学报
2003年 第16期

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