β-A抑制素基因在妊高征胎盘中的表达

Expression of beta-A inhibin gene in placentas from women with pregnancy induced hypertension

目的 :研究β A抑制素基因在妊高征患者胎盘中的表达及其在妊高征病因和发病机制中的作用 .方法 :采用RT PCR方法检测 10例中、重度妊高征患者、10例正常初产妇胎盘中β A抑制素基因mRNA的表达 .结果 :以 10例正常初产妇胎盘为表达参照 ,重度妊高征胎盘 β A抑制素基因表达明显高于对照组 (P <0 .0 5 ) .结论 :β A抑制素基因在妊高征患者胎盘中高表达可能是引发妊高征一系列病理生理变化的环节之一 ,也可能作为评估妊高征高危因素的重要参考指标之一 .

AIM: To study the relationship between beta A inhibin gene and pregnancy induced hypertension. METHODS: Expression of beta A inhibin mRNA in placentas was detected by RT PCR in a series of 10 cases with moderate or severe pregnancy induced hypertension (PIH) and 10 normotensive primipara, respectively. RESULTS: Compared with that of the 10 normotensive primiparas, the expression of beta A inhibin mRNA in the 10 moderate and severe PIH is significantly higher ( P <0.05). CONCLUSION: Beta A inhibin gene overexpression might play a part in the pathogenesis and pathologic physiology of PIH and can be used to evaluate the high risk factor of PIH.