摘要
The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system of safety, ease of manufacturing, etc. As important nonviral vectors, polymer gene delivery systems have gained increasing attention and have begun to show increasing promising. In this review, the fundamental and recent progress of polymer-based gene delivery vectors is reviewed.
The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system of safety, ease of manufacturing, etc. As important nonviral vectors, polymer gene delivery systems have gained increasing attention and have begun to show increasing promising. In this review, the fundamental and recent progress of polymer-based gene delivery vectors is reviewed.
基金
supported by the National Key Basic Research Program of China(Grant No.G1999064703)
the Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.200048604)
the Creative Fund of Wuhan University
关键词
基因治疗
基因转移
内吞作用
质粒DNA
gene delivery, gene transfer, gene therapy, polymer vector, nonviral vector.
