脑梗死患者血清碱性成纤维细胞生长因子含量变化及意义

The changes of serum bFGF in patients with acute cerebral infarction and its clinical significance

目的 观察脑梗死患者血清碱性成纤维细胞生长因子 (bFGF)的含量变化 ,探讨其在脑梗死发生发展过程中的作用和意义。方法 采用酶联免疫吸附法 (ELISA)检测 5 5例脑梗死患者、 32例其他疾病对照组和 30例正常健康对照组的血清bFGF含量。结果 (1 )脑梗死患者血清bFGF含量较两组对照组显著升高。 (2 )脑梗死患者血清bFGF含量变化与梗死灶大小关系密切 ,而与血脂水平及高血压关系不密切。结论 (1 )监测脑梗死患者血清bFGF含量变化有助于判断病灶大小。 (2 )外源性bFGF治疗对脑梗死具有重要意义。

Objective To assess the role and clinical significance of serum basic fibroblast growth factor(bFGF) in cerebral infarction by measuring the change of its level in the patients with cerebral infarction.Methods ELISA was used to measure the serum bFGF level of 55 cerebral infarction patients who were observed at two different time points:onset within 2 days and onset 2 weeks.Thirty two patients with other neurologic diseases(20 with sciatica,12 with trigeminal neuralgia) and 30 healthy people were used as control.At the same time,we analysed the relationship between the three indexes(the size of infarct,with or without hypertension or hypercholestrolemia) and the level of bFGF in serum.Results (1)The level of bFGF in serum of patients with cerebral infarction was markedly higher than those in the two control groups( P <0 01).(2)There was an obvious relationship between the size of infarct and the level of serum bFGF;while there are no obvious relationships between the level of bFGF and hypertension or hypercholestrolemia.Conclusion bFGF might play a role in the pathophysiologic process through immunologic mechanism.The level of bFGF could be a index to estimate the size of infarct. [