非小细胞肺癌中CD44v6的表达

CD44v6 expression in non-small cell lung carcinomas

目的 探讨CD4 4v6表达与非小细胞肺癌临床病理特征之间的关系。方法 采用免疫组化S P法检测 132例非小细胞肺癌、6 6例淋巴结转移癌和 115例正常肺组织CD4 4v6表达的情况。结果 非小细胞肺癌CD4 4v6阳性表达率为4 8 4 8% ,高于正常肺组织 17 39%的阳性表达率。CD4 4v6阳性表达与淋巴结转移状况、TNM分期、肿瘤大小和组织学类型有相关性。非小细胞肺癌淋巴结转移组、TNMⅢ期患者、直径 >3cm的肿瘤和鳞癌CD4 4v6阳性表达率分别高于无淋巴结转移组、TNMⅠ期和Ⅱ期患者、直径≤ 3cm的肿瘤和腺癌。淋巴结转移癌CD4 4v6阳性表达率高于肺原发癌。CD4 4v6阳性表达与患者的性别、年龄和组织学分级无相关性。结论 CD4 4v6阳性表达预示非小细胞肺癌具有较强的侵袭和转移能力 ,可作为一项预测非小细胞肺癌转移潜能生物学指标。

Purpose To investigate the relationship between CD44v6 expression and clinicopathologic characteristics in non small cell lung carcinomas (NSCLC). Methods CD44v6 protein was detected by S P immunohistochemical method in 132 cases of NSCLC, 66 cases of metastatic lymph nodes and 115 cases of normal lung tissue. Results CD44v6 positive expression of NSCLC was 48 48%, significantly higher than that of normal lung tissue (17 39%). CD44v6 positive expression was significantly correlated with lymph nodes status, TNM stage, tumor size and histological type, but was not significantly correlated with the patients' sex, age, and histological grade. CD44v6 positive expression in NSCLC with lymph node metastasis, TNM stage Ⅲ, tumor >3 cm in diameter and squamous cell carcinomas was significantly higher than that without lymph node metastasis, TNM stage Ⅰ, Ⅱ, tumor ≤3 cm and adenocarcinomas. CD44v6 positive expression of metastatic lymph nodes was 80 30%, significantly higher than that of primary lung carcinomas. Conclusions CD44v6 positive expression indicated that NSCLC has stronger invasion and metastasis potential. CD44v6 is a useful marker of predicting the metastatic potential of NSCLC.