微生态调节剂干预新生儿高未结合胆红素血症疗效和机制初探

Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation

目的 :探讨微生态调节剂 (MP)对降低新生儿高未结合胆红素血症 (UCHB)血清胆红素的疗效及机制。方法 :4 6例UCHB患儿随机分为两组 ,常规治疗基础上 ,观察组加服多维乳酸菌散 (粪链球菌、枯草杆菌 ) ;全自动生化分析仪 ,重氮偶合比色法测血清胆红素。结果 :治疗 72h后血清总胆红素 ,观察组较控制组降低明显 ,P <0 .0 5 ,日均胆红素下降值分别是 4 4 .0 6±7.2 2 μmol/L和 36 .35± 7.19μmol/L ,P <0 .0 0 1。结论 :多维乳酸菌散对降低新生儿UCHB有效。MP干预新生儿黄疸几无副作用 ,顺应了当前医药界维护人体微生态平衡的“绿色革命”。

Objective:To study the therapeutic effect and the mechanism of microecological preparation to reduce the serum bilirubin level in neonatal unconjugated hyperbilirubinemia(UCHB).Methods:Forty-six neonates with UCHB were divided into two groups.Beside the conventional treatment,pulvis polyvitamin lactobacillus(E.faecium,B.subtilis)was given to the investigated group.Total serum bilirubin(TSB)levels were determined by diazo coincidence analysis colorimetric method with full automatic biochemical analysor.Results:After the 72-hour treatment,the decreased TSB levels of the investigated group were more obvious than those of the control group, P <0.05.The average value of daily decreased TSB level was 44.06±7.22μmol/L in the former,and 36.35±7.19μmol/L in the latter, P <0.001. Conclusion: Pulvis polyvitamin lactobacillus is an effective drug to reduce the TSB levels in neonatal UCHB,and it accords with the current trend that'green revolution' in medicine to safeguard the ecological balance of human body.