期刊文献+

气道反应性测定在哮喘遗传家系的研究 被引量:1

A study of the airway responsiveness assay in asthmatic heredity family
下载PDF
导出
摘要 目的 以支气管反应性为表型 ,观察哮喘家系成员支气管高反应性的遗传关系。方法 以先证者为调查中心 ,收集哮喘家系 ,对每个家系成员进行病史调查同时作支气管反应性测定或支气管舒张试验。结果 通过支气管反应性的测定 ,在家系中诊断为哮喘病人和未诊断为哮喘的个体气道反应性和肺功能显著不同 (P <0 0 5 ,P <0 0 1) ,哮喘父母对子女患病率的影响以父亲患病对子女患病率的影响最大 (占 5 4% )其次为母亲对子女的影响 (占 46% )。结论 在哮喘遗传家系中未诊断为哮喘的个体也存在气道高反应性 ,父亲。 Objective To observe the genetic relation of airway responsiveness in asthmatic family members. Methods Asthmatic family was collected using the proband as the center. Asthmatic history investigation, airway responsiveness measurement and bronchodilation test were conducted on every asthmatic family member. Results Significant difference was found between asthmatic and asymptomatic subject of airway responsiveness and pulmonary function in asthmatic family. Asthmatic parents influenced a prevalence rate of children(father: 54%, mother: 46%). Conclusion There is airway hyperresponsiveness in asymptomatic subject of asthmatic family. Father, mother or both with asthma may have different effects on the prevalence rate of children in asthmatic family.
出处 《第三军医大学学报》 CAS CSCD 北大核心 2003年第7期646-648,共3页 Journal of Third Military Medical University
关键词 哮喘 家系分析 支气管反应性 asthma family analysis airway responsiveness
  • 引文网络
  • 相关文献

参考文献2

共引文献2008

同被引文献8

  • 1JANSEN D F,TIMENS W,KRAAN J,et al.(A) symptomatic bronchial hyper-responsiveness and asthma[J].Respir Med,1997,91(3):121-134.
  • 2BENER A,SAFA W,ABDULHALIK S,et al.An analysis of skin prick test reactions in asthmatics in a hot climate and desert environment[J].Allergy Immunol (Paris),2002,34 (8):281-286.
  • 3TOWNLEY R G,BEWTRA A K,NAIR N M,et al.Methacholine inhalation challenge studies[J].J Allergy Clin Immunol,1979,64 (6 pt2):569-574.
  • 4LONGO G,STRINATI R,POLI F,et al.Genetic factors in nonspecific bronchial hyperreactivity.An epidemiologic study[J].Am J Dis Child,1987,141(3):331 -334.
  • 5DOLD S M,WJST E,VON-MUTIUS E,et al.Genetic risk for asthma,allergic rhinitis,and atopic dermatitis[J].Arch Dis Child,1992,67(8):1018 -1022.
  • 6DUFFY D L,MARTIN N G,BATTISTUTTA D,et al.Genetics of asthma and hay fever in Australian twins[J].Am Rev Respir Dis,1990,142(6 Pt 1):1351-1358.
  • 7支气管哮喘防治指南[J].中华结核和呼吸杂志,1997,20(5):261-267. 被引量:2006
  • 8桂芹,钱桂生,江汉,赵志强.哮喘家系成员血清总IgE的遗传学分析[J].免疫学杂志,2004,20(2):131-133. 被引量:5

引证文献1

二级引证文献1

;
使用帮助 返回顶部