摘要
目的 以支气管反应性为表型 ,观察哮喘家系成员支气管高反应性的遗传关系。方法 以先证者为调查中心 ,收集哮喘家系 ,对每个家系成员进行病史调查同时作支气管反应性测定或支气管舒张试验。结果 通过支气管反应性的测定 ,在家系中诊断为哮喘病人和未诊断为哮喘的个体气道反应性和肺功能显著不同 (P <0 0 5 ,P <0 0 1) ,哮喘父母对子女患病率的影响以父亲患病对子女患病率的影响最大 (占 5 4% )其次为母亲对子女的影响 (占 46% )。结论 在哮喘遗传家系中未诊断为哮喘的个体也存在气道高反应性 ,父亲。
Objective To observe the genetic relation of airway responsiveness in asthmatic family members. Methods Asthmatic family was collected using the proband as the center. Asthmatic history investigation, airway responsiveness measurement and bronchodilation test were conducted on every asthmatic family member. Results Significant difference was found between asthmatic and asymptomatic subject of airway responsiveness and pulmonary function in asthmatic family. Asthmatic parents influenced a prevalence rate of children(father: 54%, mother: 46%). Conclusion There is airway hyperresponsiveness in asymptomatic subject of asthmatic family. Father, mother or both with asthma may have different effects on the prevalence rate of children in asthmatic family.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第7期646-648,共3页
Journal of Third Military Medical University
关键词
哮喘
家系分析
支气管反应性
asthma
family analysis
airway responsiveness